13-year antibiotic resistance trends in bottling dolphins – ScienceDaily


Antibiotic resistance is one of the biggest public health challenges in the world today, as many bacterial infections develop into drugs used to treat them, and new antibiotics do not develop fast enough to solve the problem.

Primarily primarily restricted to health, these resistant strains of bacteria are now commonly found elsewhere, especially in the marine environment. To date, several studies have examined long-term trends in antibiotic resistance in pathogens isolated from wildlife populations.

Florida Atlantic University's Harbor Branch Oceanographic Institute researchers in the aquarium of the Georgian, South Carolina Medical University and Colorado State University conducted by the employees of resistance to antibiotics is a unique, long-term study (2003 to 2015), antibiotic resistance is a unique, bottle Delphi Will the isolated pathogens (Tursiops truncatus) in the Indian River Lagoon in Florida. This lagoon has a large coastal population and has significant environmental impacts.

"In 2009, we noted a high prevalence of antibiotic resistance in wild dolphins, which was unexpected," said Adam M. Schaefer, MPH, lead author and epidemiologist at FAU's Harbor Branch. "Since then, we observe changes over time we and the animals from the isolation of antibiotic resistance found a significant increase. This trend is a mirror of human health care settings. Source, the regular use of antibiotics, which are potentially included in the marine environment to human endeavors for terrestrial sources or discharge. "

Using 13-year data and multiple resistance indexes to antibiotics, the researchers obtained a total of 733 pathogenic isolates from 171 individual bottlenose dolphins. Several organisms isolated from these animals are important human pathologies.

The results of the study, published in the journal Water mammals, Show that the overall prevalence of resistance to at least one antibiotic on 733 isolates was 88.2 percent. The prevalence of resistance was highest with erythromycin (91.6 percent), followed by ampicillin (77.3 percent) and cephalothin (61.7 percent). This is one of the few studies to use the MAR index for bacterial isolates of marine mammal species.

Resistance to ciprofloxacin among E. coli isolates has more than doubled between sampling periods, reflecting recent trends in human clinical infections. Pseudomonas aeruginosa, which is responsible for respiratory system infections, urinary tract infections, by the way, is the highest reported for any organism and increased during the study period.

The MAR index was significantly increased compared to 2003-2007 and 2010-2015 for P. aeruginosa and Vibrio alginolyticus, a common pathogenic marine Vibrio species that causes productive seafood. For all bacterial isolates, resistance to cefotaxime, ceftazidime, and gentamycin increased significantly between sampling periods.

"Health and environmental risk assessment or HERA project contributed to clarify that botliozul dolphins antibiotic bacterial resistance prevails. Botlenozis dolphins precious sentilinuri species, help us to understand how to apply it to human and environmental health. HERA-'s, we were able to hold fast to debinat information on a database in order to continue studying these impressive animals. "- said Gregory D. bosartma, VMD, Ph.D., co-author, senior vice president and chief veterinary officer of the aquarium." Antibiotic resistance is one of the most significant risk to public health. As resistance increases, the likelihood of successful treatment of infections caused by common pathogens decreases. "

Selection work for the study was conducted and partially funded by Florida Specialty Licensing Platform and Georgia Aquarium by Bossart, both under the direction of HERA management and permit holder. For microbiology the cargo samples were taken from brophil, gastric fluid and feces and sorted on standard media under aerobic conditions. The most frequently isolated pathogens were Aeromonas hydrofila, E. coli, Edwardsiella tarda, V. alginolyticus, and S. aureus, pathogens frequently associated with the aquatic environment. Dolphins were captured and released in the Indian River Lagoon as part of the HERA project. The sampling was done in June and July of each year.

"The human health impact of the pathogen Acinetobacter baumannii is of major concern nationwide as it is an important nosocomial pathogen that has been associated with rising infection rates for the last 10 years," said Peter McCarthy, co-founder, research professor and associate director at FAU's Harbor Branch of Education. . "In addition to nosocomial infections, globally resistant strains associated with fish and fisheries have been shown. Globally, there has been a high bacterial index that has been isolated from dolphins against these bacteria."

In the United States, at least 2 million people each year receive antibiotic-resistant infections, and at least 23,000 people die.

Research co-authors are Tyler Harrington, FAU's Harbor Branch; Patricia A. Fair, Ph.D., Medical University of South Carolina; And John S. Baker. Reiff, PhD at Colorado State University.

This work was partially funded by conservation funds provided by the Wild Dolphin Licensing Platform, which received funding from the Harbor Branch Oceanographic Institute and the Georgia Aquarium.

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