3D printing will come to mind…

The first batch of science and technology project review meetings held on Friday unveiled the mysterious Jihua Lab. This strategic science and technology innovation platform, which aims to build a national laboratory, has attracted a lot of attention to how to simultaneously target the key national technology needs of the major national special projects and Foshan industry, and how to serve the country’s major strategic needs and serve local economic development. Our reporter experienced the project review meeting, which is the unique charm of these cutting-edge science and technology projects for readers.

Front edge project

Future 3D printing can make brain tissue

With 3D printing technology, you can Create active human tissue? In the not too distant future, this will no longer remain at the level of scientific fantasy. “In the future, people’s pursuit of quality of life will become higher and higher. As the forefront of international manufacturing technology, 3D printing living life organization will be the direction of future national people’s livelihood strategy and emerging industries.” At the project review meeting, Xi’an Jiaotong University, Changjiang special hire Professor Li Dichen said that the project will focus on common human diseases, including cartilage and bone tissue, breast tissue, multi-layer skin tissue, brain and nerve tissue. The project is supported by cutting-edge applications and basic research. Li Dichen hopes to form a platform for laboratory support to incubate the fruits of innovation.

In the study of cartilage and bone and joint tissue manufacturing, the goal of the Li Dichen team is to create a scaffold constructed together with cartilage and bone tissue to allow the cartilage and bone to be combined to repair large segments of cartilage. Tissue defect. In breast tissue manufacturing research, the goal is to create a degradable active breast stent that is currently in clinical use. “The skin tissue produced in the past has only one surface layer, and there is no function of aeration and release of sweat.” Li Dichen then introduced that the manufacture of multi-layer skin tissue belongs to the cell 3D printing technology and is now being tested in mice. For brain tissue manufacturing, the topic is not only to provide solutions for repairing the brain, but more importantly to provide models for brain science research, to achieve the growth of multi-layer 3D printed structures of brain tissue in the culture environment.

“How soft tissue fits and integrates with human tissue, how soft and hard tissue interfaces are formed, how high-precision multi-cell printing survives and symbiosis – these are new trends and challenges in research We hope to develop research in this area from design, manufacturing to function formation, including design, materials, processes, equipment and functional systems.” Li Dichen said that the future direction is to print brain tissue and nerves in 3D. Organizational development. The scientific issues that his team is now trying to solve include how the human tissue should be designed at the macro and micro levels; how to achieve multi-material human tissue manufacturing; how to maintain the activity of 3D printed tissue, and how to make it coexist with the human body.

How many “top days” do you decipher?

Influence of international leadership

Since the early 1990s, 3D printing of in vitro medical models and instruments has emerged. Around 1995, 3D printed “substitute” of human tissue appeared in the world, but such “substitute” implanted in the human body is not active. From 1998 to 2003, 3D printing was developed in the direction of active tissue research (ie, tissue engineering scaffolds); before and after this, research on cell 3D printing began to appear.

In 2001, the Li Dichen team used 3D printing technology to make the mandible. His results are ten years earlier than the clinical application abroad. In 2016, the team made a tissue engineering scaffold for the trachea and breast. “These two studies are the earliest in the world. In the research of 3D printing of cells (that is, the technology of multi-layer skin tissue manufacturing, brain tissue and nerve manufacturing), they have not entered clinical application at home and abroad.” Li Dichen said. I hope to promote 3D printing of human tissues and organs, from artificial prosthesis to active tissue, from hard tissue to soft tissue manufacturing.

Expert questions

How long does it take to achieve industrialization?

From a foreign perspective, Harvard University, the Massachusetts Institute of Technology, Wake Forest University, the University of Michigan, and the Queensland University of Technology in Australia are engaged in such research. Among them, in the research of printing vascularized degradable soft tissue and degradable tracheal stent, Li Dichen team can “run and run” with the team of Harvard University and University of Michigan. “We are catching up with the international advanced level. It is entirely possible that the general trend of research is developing towards active organizations.” Li Dichen said that in medical applications, the Fourth Military Medical University and the Shanghai Ninth People’s Hospital of Shanghai Jiaotong University have started clinical research.

For the project, there are review experts who propose how long it will take to industrialize? “We hope to go to Guangdong (Foshan) to quickly realize the industrialization of the results.” Li Dichen said that the study of 3D printing mandibles took the case of applying for registration to the drug regulatory department in 2004 and has been registered for 14 years. This year, the state began to issue relevant guidance documents, which is inseparable from the promotion of scientific research. He further stated that the process of industrialization is not only a solution to the problem of technology, but also hopes that technology can lead to the promotion from the technical, management and policy levels.

Reporter’s observation

“Site” project

How to break through scientific issues?

In addition to the country’s major strategic needs, the “Dingtian” project was short-listed. At the first batch of project review meetings, a number of projects related to industrial transformation and upgrading and local economic development were shortlisted. This includes intelligent flexible automated production lines for automotive wire harnesses that change the domestic production of tens of billions of automotive wire harness industries, as well as smart flexible garment technology and equipment aimed at the trillion garment market. “These ‘site’ projects must first solve the key technologies that need to be solved in Foshan and even in Guangdong and the whole country.” Director of the Jihua Laboratory and Director Cao Jianlin further expressed the expectation that these projects will promote the development of China’s manufacturing industry. .

For example, the artificial lighting system development project that will change the pattern of soy sauce brewing industry, the breakthrough of this project is to fill the research gap of the world’s light soy sauce drying technology and equipment, and even cut it into this. Point to realize the intelligent manufacturing of soy sauce. As the project leader, Liu Muqing, a professor at the Institute of Engineering and Applied Technology of Fudan University, said that he hopes to use the LED spectroscopy system to irradiate the fermenter to achieve complete control of the light in the soy sauce brewing, and further enhance the flavor and quality of the soy sauce by controlling the light.

A imaginative application of basic research projects, is it possible to make breakthroughs in solving scientific problems? At the project review meeting, some review experts pointed out that the relationship between light and soy sauce flavor is related to scientific issues, which is the innovation and difficulty. This view has attracted the attention of other review experts. Some experts suggest that you can start from a small amount of production and further try to make the national standard of soy sauce flavor. In addition, how flavor affects human health requires basic research.

In general, Jihua Lab adopted “semi-directional” and “basic orientation” in the process of introducing technology projects while ensuring that the project can be “top” and “place”. The way is to let the team and user units (enterprises) that are most capable of solving scientific problems in China participate together to propose a preliminary project plan. Cao Jianlin said that in this process, it is necessary to conduct extensive research and plan the most need to solve the problem of “topping the ground”, and then bring these issues to discuss with the technology team. This is of great significance to ensure that these projects are “flying to the ground”.