On November 9, the 6th International Human Micro-Ecology Conference (IHMC 2016) was held in Houston, USA. More than 400 people from nearly 20 countries around the world participated in the conference. A number of top industry experts shared their latest research results, let us take a look at the progress of microbial genomics in medical research.
Intestinal flora affects infectious diseases
The Li Lanjuan academician from Zhejiang University has been working for more than 40 minutes. The opening report, the amount of information is very large.
Li Lanjuan is an academician of the Chinese Academy of Engineering, a professor of the Medical Department of Zhejiang University, a doctoral tutor, the chief physician of the First Affiliated Hospital of Zhejiang University, the director of the State Key Laboratory of Infectious Diseases and Treatment, and the leader of the national key discipline. Dr. Qin Nan and Academician Li Lanjuan jointly published an article on the relationship between cirrhosis and intestinal microbes in Nature.
In this opening report, Academician Li’s report entitled: Intestinal Flora: A New Field of Targeted Therapy for Infectious Diseases (Gut Microbiota: A New Territory of Therapeutic Targeting for Infectious Disease). The report covers the research results of Academician Li in the field of infection and microbiology, including research on intestinal microbial and liver diseases, C. difficile infection and HIV infection. The report recently mentions that the microbial composition on the tongue is clearly characterized in patients with cirrhosis. In addition, she also mentioned the use of probiotics to improve some of the above diseases.
Intestinal microbiology research still has many problems to solve—Professor Dusko Ehrlich
Dusko Ehrlich is the French National Academy of Agricultural Sciences (INRA) researchers are also the main implementation and participants of the European MetaHIT program.
At this meeting, Professor Dusko Ehrlich introduced the challenges of microbiology research (Challenges in Microbiome Research). Mainly include: the standardization process is still lacking, the normal human reference gene set needs data integration in multiple places, the integration of clinical data and omics data, the influence of drugs on intestinal microbial detection results, the microbial instability of individuals and Microbial recovery methods are facing enormous challenges.
What are the achievements and new developments in the HMP project? –Professor Owen White
Owen R. White is a professor in the Department of Epidemiology and Public Health at the University of Maryland School of Medicine in Baltimore and a Bioinformatics Institute at the Genomics Institute. Department Head (IGS). The lead agency for this division is the Central Data Repository or the Coordinated Data Analysis Center (HMP DACC) of the Human Microbiome Group.
Owen R. White is full of personality, not only with a black and white beard, but also with a large earring on his left ear. At this conference, he shared a report on the Prospects from the Human Microbiome Project and a Step Toward the Future. In this report, he reviews the history of the HMP project and the achievements of the HMP project. The project used a genome sequencing method to detect 2,280 samples, including 17 body parts, 3 sampling time points, and the cities of Houston and Boston. The results of this study update a number of algorithms, and the results of the annotations are mentioned. The ongoing multi-omics based human microbiology research (iHMP) is also mentioned.
Where is the direction of human microbiology research? –Professor George Weinstock
Professor George Weinstock is a member of The Jackson Laboratory, focusing on microbial and infectious disease research, next-generation sequencing (NGS) technology and the use of microbial macros Genomics has done a lot of work on infectious disease research. Many computing tools have been developed to manage genomic big data.
At this meeting, Professor George Weinstock gave an Evolving Studies of the Human Microbiome and an Overview of the Next Three Days. report. Before the report began, he first introduced the results of American universities with a few films. He expressed surprise at the election of Trump.
In the report, he also compared the differences between American HMP and European MetaHIT. HMP focuses on the detection of human health microbiomes, including multiple body parts, and microbial composition of different people. MetaHIT focuses on intestinal diseases, the sample is only feces, and the concept of “gut type” is proposed.
At the end of the day, he also presented his own views on the future direction of human microbiome research. He believes that future research will rely more and more on computers, cloud computing and other technologies. Detection methods are not limited to sequencing, gene chip, flow cytometry and mass spectrometry.
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