A group of scientists has developed a device that can cause a partial hyallab regeneration of adult couples on African clawed frogs (Xenopus laevis) "kick-starting" tissue repair on amputation. Their conclusions appeared on November 6 in the journal Cell reports, To develop a new model for "electric motors" or to test the stimulation of the cells.
"The best, adult frogs normally grow only barren, thin, cartilaginous spike," says senior author Michael Levin, development biologist at Allen Discovery Center in Tufts University. "Our procedure has never been caused by the regenerative response they have never had, which has resulted in greater, more structured additives, and the bureaucratic device has made very difficult steps that biogenerers should not have been directly on the microphone."
The scientists were photographed from the silicon bio hornster and filled with hydrocarbons – polymer glue globes. They feed hydrogen silk proteins, which promote therapeutic and regeneration, and then add the progesterone. Progesterone is known for preparing a pregnancy uterus, but the hormone also shows the repair of nerve, vascular and bone tissue.
The researchers divide frogs into three groups: experimental, control and sham. In the experimental and shampoo group, they carried the guns on the frogs. In the experimental group, the bioforector was released on the amputation of progesterone. In all cases, they were released 24 hours later.
When they studied the experimental group frogs at different times for more than 9.5 months, they noticed that the bioreactor caused the degree of ligament regeneration in other groups. Instead of a typical spike-like structure, bio-heterogeneous therapy is followed by a paddle-like formation that is closer to the limbs than the creation of impossible regeneration.
"The bio-equipment tool has created a favorable environment where tissue development can develop as embryogenesis," says Levin. "The bureaucracy and the very brief reset of its reset have caused months of tissue growth and modeling."
Levin and his team closely looked at the molecular and histology analysis of regenerated structures. They saw that the regenerative limbs of bio-oxygen-treated frogs were more bone with bones, inverting and blood vessels, rather than control and built-in groups. Frog videos were filmed in their tanks, and they also noted that the frogs pushed more camps into frogs.
The consistency and transcriptional analysis of the RNAs demonstrate that the bioretransmitter has changed the genetically modified substances in the amputation cells. Genes with oxygen stress, serotonergic alarms and blood-white cells have been irregular, while some other genes associated with alarm were regulated.
The researchers also noted that scars and immune reactions in the scars containing scars were regulated, suggesting that the addition of progesterone caused a natural reaction of the body to the effect of the regeneration process.
"Both reproduction and its newly discovered role in brain function, progesterone's actions are specific to local or tissue," says Celia Herera-Rincon, a neuroscientist at Levin Laboratory at Tufts University. "By this approach we demonstrate that reproduction, brain processing and regeneration are closer than we think maybe they share common and elements that do not fully understand the biometric code."
The Levin Laboratory continues the expediency of biselectric processes to create a spinal cord regeneration and tumor reproduction. They also hope that bisectors experiment with mammals. Previous research suggests that the mice are partially regenerating handcuffs in favorable conditions, but their life prevents the process from landing.
"Almost every good regenerator is water," says Levin. "You can imagine why this is a matter: a mouse that loses hands or hands and then forms liquid regenerative cells for flooring as a footprint, is less likely to regenerate a significant limb."
Levin plans to monitor further sensors for optical monitoring and optimal stimulation, which hopes to improve control over cellular solutions.
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