Cancer radiotherapy experiences defects, such as resistance to hypoxic cells, excessive radiation that results in further healthy tissue damage and accompanying side effects. Therefore, radiotherapy is sensitive to improved radiotherapy effectiveness and a relatively small radiation dose is desirable. In this study, the Nanosystem is based on the poly (lacto-Co– Glycolic acid (PLGA) and ultraviolet black phosphoric quantum spots (BPQDs) are designed and prepared for radiosensitization of the precision tumor. PLGA nanoparticles will act as a BPQD package to prevent off-target release and rapid degradation during blood circulation. The nanosystem, aimed at the polypetics peptide motivation, is actively collecting in tumor tissues. 2,3-dimethylmaleic anhydride shell decomposes in acidic microenvironment and nanoparticles become positively charged, thus supporting cellular uptake. In addition, the GHD de oxidizes the cystic dysfunction connectivity and consistently leads to BPQD allocating the cells of sensitive tumors with X-ray therapy. Treatment using PLGA-SS-D2 BPQDs Nanosystem and X-ray leads to cell apophths that have been linked to reactive oxygen species. In in vivo Research, nanosystem shows the effectiveness of sensitive radiotherapy, but minor histological injuries of the main organs. This study envisages designing and frauding the surface responsibilities of the surface and pH-response nanosystems as strong radioscosystems to ensure the efficiency of sensitive radiotherapy and minor toxic side effects.