It was difficult for nanotubes to simultaneously meet the demands of prolonged blood circulation, cell gain, rapid lysosomal escape, precise drug release, and tumor drug delivery. To overcome this dilemma, we prepared a nanotransformer (DTIG) with a series of doxorubicin, tannic acid and indocyanine. Hydrophilic DTIG showed prolonged circulation time. In addition, DTIG can effectively reduce tumor cells by converting hydrophobic particles into acidic tumor microenvironment. Subsequently, large hydrophobic particles were subsequently formed into acidic lysosomes, to escape from it, by decomposition of the lysosome. These hydrophobic DTIGs can rapidly return to smaller hydrophilic nanomaterials and release loads into the cytoplasm. Like protein denaturation and denaturation, these highly efficient instant transformations were activated by the proton. However, photothermal therapy with DTIG promotes drug penetration into the tumor effectively. This process optimized for DTIG drugs eventually offered strong antitumor efficacy and a clear advantage over prognosis.