Domestic escapes have quietly occurred in the field of biotechnology

Domestic Escapes happen quietly in the field of biotechnology

Emergency exits often underestimate biotech returns. Unlike most technology deals, BIO’s maximum profit usually occurs long after an IPO or acquisition.

In the case of Juno Therapeutics, a publicly traded cancer immunology company, sold to pharmaceutical giant CelGeNe for $9 billion this year, which does not seem to affect Zhu. Novo early investors.

After all, Juno made a public appearance in 2014. Although the Seattle company raised more than $300 million as a private company, former IPO supporters have spent several years trading in healthy multiples for cash.

However, some people insist. Bob Nelsen, managing director of ARCVieldPartners, Juno’s largest venture capital firm, told CuncBaseNews that when CelGein acquired the company, his company still held all of its 15% IPO shares.

Finally, the acquisition of the limited partner of the network arch bridge 23 times the funds, bringing nearly one billion dollars. This is an extraordinary return, even if it is a risk-running standard. 1.

“We tend to be at milestones, not financing events,” Nelson said, his company’s approach to exiting the portfolio. This usually means holding for years after waiting for positive clinical trial results or other IPOs that create inflection points.

For listed companies, this can be done over time or in one go, usually in the form of company stocks, not cash.

So when is the exit?

The results like Juno help explain why life sciences, despite bringing less first-day IPO POPs and buzzing unicorn exports than the tech department, still attracts about The third venture capital. Large exports do happen. But usually, this is not a big publicity, and it is usually not publicly listed.

“I don’t think IPO is the way out for biotechnology. “This is always a financing event,” Nelson said. Although ARCH may hold a longer stock than a typical VC, he said, It’s not uncommon to put stocks on hold after the IPO.

On other occasions, IPOs and holding strategies seem to be good for the company. Other listed companies were later acquired billions of dollars, including receptionists, drug development, And Kaisera Biopharma, the most famous injection, can reduce chin fat.

Using CunkBasic data, we have seen the sale of billions of dollars after a few years after the venture capital biotech company went public. Over the past five years, we have found that at least eight companies are selling for 2 billion years or more, less than four years before the acquisition. In general, these acquisitions are worth more than $47 billion. /p>

Domestic The escape event quietly occurred in the field of biotechnology

Post-IPO benefits

It is not uncommon for biotech startups to grow into billions of dollars in IPOs a few years later.

With CunkBasic data, we list a dozen Data from a life sciences company that has been listed in the past five years, with recent market values ​​ranging from $1.5 billion to nearly $9 billion. (This is a sampling, not a comprehensive data set, and based on several top life science VCS Export assembly.)

Domestic escape has quietly occurred in the field of biotechnology

The latest is the gene therapy giant Bluebird Bio, which has risen seven-fold since its launch five years ago, followed by SGE therapy, a developer of central nervous system disease treatment that has grown six-fold since its initial public offering four years ago, reaching nearly 80 A market cap of $100 million.

Therefore, in terms of equipment, there is a portable oxygen concentrator for respiratory diseases. Manufacturer. It is publicly traded at less than $300 million for $2014. Today’s value is about $4.3 billion.

Yes, real technology stocks can see huge gains in the years after going public. But drivers are usually different. In the technology sector, a company may see its stock jump after sales have risen sharply, but it may have sold in the first few quarters. The business has not changed radically, it has only improved.

In addition, technology venture capitalists generally consider IPOs to be an exit. Although insiders usually can’t sell stocks immediately, they usually feel comfortable cleaning when they can around IPO prices.

For biology, key milestones change the entire value proposition. A company can have one or two of these things from no-market products and no sales to fast.

Milestones and Money

As a result of the widespread use of milestone payments, the benefits of biotech startup mergers and acquisitions are difficult to determine. Buyers pay higher prices, along with more favorable clinical trial results and commercially successful treatments.

In general, if you reach a milestone, more multiples will appear. One of the most influential private companies to withdraw from biomedicine. Selkin bought the company for $1.1 billion. However, the valuation of the deal could be as high as $7 billion.

But it seems that the probability of hitting all milestones is low. In order to get a full $7 billion, global net sales of impact therapy will exceed $5 billion annually. However, some milestones seem more feasible, such as the $1.25 billion in payments approved for regulatory approval.

This transaction structure is very common, not just mergers and acquisitions. A study by the medical news site StAT analyzed nearly 700 biotech licensing transactions and found that on average, only 14% of the total value was paid in advance.

As with the return on IPO acquisitions, it is difficult to measure how well investors are in these milestone purchases. The biggest reward may be a few years later.

The opposite of technology

If the dynamics of a bio-export seem to be contrary to technology exports in many ways, it is worth considering how different the two industries are at an early stage.

In the world of technology entrepreneurship, a company that launches a stupid idea (tweet, scooter sharing, air mattress rental), and then suddenly worth billions of dollars is very common.

The bio company is the opposite. In fact, each sounds like a great idea (cure cancer, relieve pain, treat neurodegenerative diseases), and many of the results are worthless. However, the investment may take a while, but it will eventually be achieved in a huge way.

At the various stages of the investment, earning 23 times the money is unusual. However, when it does happen, the seed stage of investment is the most common, where the number of investors is one in a million or less. In the case of ARCH, 23 x, this is a particularly high return because it contains all the rounds that Juno proposed before the disclosure.

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