Formation of artificial peptide bonds ensures the creation of life on earth


Formation of artificial peptide bonds ensures the creation of life on earth

Polyppeptic formation with oxidative reaction of amino-tiocaits. (A) amino tyocytes 1 and 2 form the intermediate and subsequent intramolecular amide formation of diaphinous dyspholphy together with the alpha-amide bond. Iron ore or Fe2O3 acid solutions accelerates the formation of this polypeptide. Repeating effect of this reaction will generate polypeptide. (B) Polypeptide is formed by white sediment. Credits: Osaka University

The main composition of cells, tissues, organs, and organisms is proteins that build amino acids in order to form long-term protein chains polypeptides. Although live cells carry advanced techniques, this chain can expand the speed and accuracy of the laboratory reaction to produce natural peptide products or peptide preparations relatively comparable to raw and hard work.


Amino acids variants Called the University of Oncas, to overcome these problems to achieve the exact and simple expansion of peptide chains during rapid response. Their work published in the journal Biochemistry, Also suggests that billions of years ago, this particular chemical mechanism could have a complex complex of molecules that could potentially provide the conditions in which life eventually appeared.

In this study the team highlighted the improvement of previous efforts, which artificially synthesized with polypeptides, in which the main obstacle was the involvement of protective groups. Such protective groups have added functional groups to the molecule to ensure a further reaction to the concrete. However, they should perform multiple reaction stages, which are ineffective in the procedure.

"Our efforts to improve the artificial peptide bond formation, rather than focusing on amino acids, we see instead in amino tioids that contain sulfur atom," says Yasihiro Kajihara. "We started the phonilanine amniotic version as a monomer, and the reaction was only five minutes, that the peptide chains contained two to five phenylalanins, and the alternatives were found in chains 12 phenylalanine."

Formation of artificial peptide bonds ensures the creation of life on earth

Iron ore surface amino thioacids by polypeptide-generating image in acidic solution. Credits: Osaka University

The team has shown that the peptide chain has been expanded with amino thyoyats and also in acidic conditions that suggest that oxidation was a key mechanism. The team confirmed the characteristic of this reaction and also showed that it was involved in a reaction medium that ensured that the product was exactly the same.

"Considering that the extension of chain amino acids is a key factor in life, we thought, millions of years ago, Amino Tiocoks could have a more complex chemist predecessor, which contributed to the development of the visibility of their fast and simple composition of chains," says Ryo Okamoto. "We found that the reaction of oligomerations was also undergoing chemical conditions such as before the Earth's lifetime, using reaction components such as iron ore and sulfuric acid that could originate from volcanic gas."

Thus, the team's activity is not only effective practical laboratory instrument but also for a number of practical applications, but also the potential for chemistry from which life began.


Researchers quickly and efficiently develop the chain of amino acids


Მet Information:
Rio Ochamoto and others. Regiooselective α-peptide bond formation of amino tioaccites, Biochemistry (2019). DOI: 10.1021 / acs.biochem.8b01239

Provided by
Osaka University

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Formation of artificial peptide bonds ensures the creation of life on earth (June 18, 2019)
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