Circulatory exosomes produced by the tumor have the potential to biomarker, which will significantly improve the treatment of cancer. However, effective isolation of exosomes remains a major technical challenge. This study presents the novel nanostructured polymer surface for effectively capturing exoskeletons through strong avidia. A variety of surface configurations consisting of multivalent dendrimers, PEG, and tumor-containing antibodies were tested using exosomes isolated from tumor cell lines. We have found that the dual layer dendrimer configuration has the highest efficiency in obtaining cultured exomes in human serum. Significantly, the optimized surface accumulated> 4 times more tumor exoskeletons from plasma samples from head and neck cancer patients than from healthy donors. By nanomechanical analysis, using an atomic force microscope, it was also found that the amplification compensation was given by multivalent tightness (aviability) and small distance attachment mediated by dendrimers. Our results support the fact that the surface of the dendrimer detects tumor exotomes under conditions of high sensitivity and specificity, demonstrating its potential as a platform for liquid cancer biopsy.