Cell-based therapy is a promising clinic strategy that includes a number of medical needs. However, engineering cells face several unavoidable challenges, such as limited cell resources, epigenetic changes in cells, and short shelf life. in vitro Culture. Here, worm-like nanocell mimicry occurs to effectively engineer tumor cells in vivo With a synergistic combination of surface engineering of a non-genetic membrane and with encapsulation inside on the place Merging of the cell membrane. Specific targeting and deformation of nanocell mimics play an important role in membrane fusion mechanisms. Engineered primary tumor cells improve the penetration of therapeutic load tumors with the help of Cellular vesicles, and tumor cells with engineered circulation (CTCs), can invade homologous cells to form CTC clusters in the bloodstream and eliminate CTC clusters in the lungs, thus achieving excellent antimicrobial and antimetastatic efficacy. First of all, we encounter an intriguing event, on the place The fusion of the cell membrane with worm-like Nanosel mimics and our discovery on the place The fusion of the cell membrane led us to the engineering of tumor cells in vivo. The present study would be a particularly important strategy for direct engineering of cells in vivo On cell therapy.