Bacterial supplementation and biophil formation Main challenges are the optimal efficiency of inventory devices. Current covering methods have significant flaws, including long-term lack of long-term activity, adaptation of simple application and variety of materials. Here we describe the cover method that can overcome such restrictions and yield ultrathin coating in long-term antibiotics activity. We used a wide range of interaction between antibiotics / nanoparticles and ultrasonic molecular weight (uHMW) hydrophilic polymers of polypsapine (PDA) antibiotic activity. We used short-term bacterial adhesion analysis as an initial screening method to prove coatings that give superior performance and found that only selected polymers (13 different types) and molecular weight showed antifungal activity. PDA self-assembly optimization, polymer PDA interaction and surface placement using uHMW polygonN, N(DMA) (~ 795 kDa) stabilized ultrathin cover (~ 19 nm) with excellent antibiotics and antibiotic properties (> 4 weeks) against a wide variety of bacteria (~ 108 CFU / mL) under conditions of shaking and conditions. The ultrathin coating is effective in a variety of substrates, including metals and polymer substrates. UHMW PDMA is a stable cover with the help of Siromolecular interaction with the PDA and the surface formed, which is highly enriched with PDMA watercolor. Based on Surface Analysis, we also offer a stable cover formation mechanism. The molecular weight of the PDMA is a decisive factor, and only uHMW polymers generate this property. Attractive feature cover is that it does not contain antimicrobial agents and has the potential to prevent biophase forming a variety of applications in both short and long term.
Supporting information is free at ACS publications website: DOI: 10.1021 / acsnano.8b05512.
Support experimental details; XPS data; ATR-FTIR spectrum; Measuring water contact corner; Stability data; Protein adsorption; Platelet adhesions, stream configuration; Cell viability Photograph of various solutions; AFM image; TEM image; SEM image; Detailed information on polymers and cover features (PDF)