Inspired by heat shock proteins (HSPs), self-constructing nanocepharon (nChap) develops as a new nanoxica to enhance antiemorrhagic immune responses. Taking advantage of HSP-like microdermabrasion and superficially decorated mannose, this nChap can effectively remove antigens and transmit them by dendrites to dendritic cells (DCs). Subsequently, nChap can explode lysosomes by transforming the structure and property of surface microdomines, thereby facilitating the escape of antigen and enhancing the presentation of their cross in cytoplasm. As a result, nChap-based nanoxin can produce immune responses based on both CD4 + and CD8 + T cells and shows excellent prophylactic action for melanoma. Further combination of nanoxin blockade of the anti-program death -1 (anti-PD-1) checkpoint offers effective inhibition of already established melanoma growth. Thus, NCOP-based Nanoxia offers a simple and powerful strategy for imitating HSPs by pressing the structure with the help of antigens, mediating surface receptors to realize DC internalization, as well as activating humoral immunity and cellular immunity by activating the immune system.