Alzheimer's disease (AD) is a progressive and irreversible brain disorder. Recent studies have shown a significant role in β-amyloide (Aβ) in AD. However, there is no conclusion that existing therapeutic strategies have influenced the reduction of Aβ-caused neurotoxicity and simultaneously eliminating the Aβ aggregate in vivo. Therefore, we have created a novel nanocopus which can eliminate toxic Aβ aggregates and reduce Aβ-induced neurotoxicity in AD. This nanocomposite was a small size particle (14 ± 4 nm), which combines the Aβ-compulsive peptide (KLVFF) surface. The nanocomposite was prepared on the packaging of the protein molecule that crosses the link-related KLVFF-containing polymer layer in situ Polymerization. The existence of Nanocomposite has been substantially changed by the Aβ aggregates morphology, which resulted in the formation of Aβ / nanocomposite coassembled nanoclusters instead of Aβ's oligomes. The reduction of abnormal Aβ oligomes, nanocomposites attenuated Aβ-caused neuron injuries, regenerated endocrinal microglia capacitance phagocytose Aβ, and ultimately protected against hypogamy neurons Apoptosis. So we think that a small amount of nanoscopy will potentially offer you a modern strategy.