Nanoparticles could find better drugs for "Walsing"


Nanopart "dancing pair". A pair of red and green was mixed with a fluorescence microscope for molecular detection. "Credits: Ian Yu, University of Indiana

Indiana University researchers have discovered that nanoparticles nurture their objects differently based on their position when they meet as ballroom dancers who change music.


The study was published in the No. 13 Journal ACS NanoIt is important, since the therapeutic particles "movement" when they connect to cells of the cells receptor can indicate the effectiveness of drug treatment. The effectiveness of immunotherapy, which uses the use of its immune system in the body, such as cancer, such as cancer, depends on the effect of cellular bonds being "perfect".

"In the majority of cases, the effectiveness of drugs is not based on the target receptor on the cell, but how strongly it is," said Professor Blummington, a professor of chemistry at the College of Arts and Sciences, who conducted research. "Better we can follow this process, the better we can scan the therapeutic effect on the screen."

Before this study, researchers thought the particles were slow and taken to the trap when they were connected to the receptor in the cell.

"But we've also seen something new," Yu said. "We saw that the particles were transformed differently when they were compulsory for their receptors."

I have never seen this because the molecular movement of Valsia, then the scientists looked at only one dancer.

Indigenous researchers at the Indian University say that the "activated" particles nanoprofi as a healthy human t-cell in order to determine the molecular dancing these particles pass through the cellular mandatory period. Credit: NIAID

In order to study, Yu's team introduced dance partners. It was two nanoparticles – one painted green, the other red that was visible with a fluorescence microscope with the formation of a joint image marker. This "nanopper" has been replaced by a cell membrane cover from T lymphocytes, a white blood cell type that plays a role in the immune system of the body.

The two colors are permitted by researchers to simultaneously observe the "rotation movement" – in place and "translation motors" – moving particles into physical space before entering the cell.

"We found that the particles began to rotate randomly, movement of movement, then round movement, and finally the movement," said Yum. "This wide range of observation of rotational movement and transition in one form over the next time the different points are completely new."

Moreover, researchers were able to start uniting other brands of this different movement.

The group has chosen to "distort" the synthetic particles of the cell membrane because these particles are not excluded by the body's immune system as foreign objects as normal synthetic particles. The use of the body's own membrane membrane also excludes the development of complex surface properties that connect to specific cells after they are already in the existing membrane.

Monitoring "waltzing" of irritated T lymphocytes to understand their target-binding tumor cells is the next phase of their research, Yu said.


Learn further:
Camouflaged nanoparticles use protein to kill cancer

Მet Information:
Yanqi Yu et al, "Waltz" of Cell membrane-covered nanoparticles on lipid bilayers: Tracking one particle rotation in Ligand-receptor binding, ACS Nano (2018). Doyle: 10.1021 / acsnano.8b04880

Journal Reference:
ACS Nano

Provided by:
Indiana University