According to a new paper published in the journal Nature Compounds, it has been found in plants traditionally used in Southeast Asia to treat arthritis and rheumatism. More powerful anti-HIV compounds than the drug AZT.
This compound is called patentiflorin A. It is derived from a plant called Justicia gendarussa, which is different from 4500 multiples. The plant extract is screened for the effects of the HIV virus.
This discovery is one of the results of a multi-year research partnership between the University of Illinois at Chicago, the Hong Kong Baptist University and the Vietnam Institute of Science and Technology. Funded by the National Institutes of Health, the National Science Foundation, and the US Department of Agriculture, these organizations look for natural products that may be used in health and medicine, and are committed to supporting the sustainable use of these resources in low-income countries.
Lijun Rong, Professor of Medical Microbiology and Immunology at UIC University, Harry Fong, Deputy Director of the World Health Organization Traditional Medicine Program, and Doel Soejarto, Professor of Pharmaceutical Chemistry and Biopharmaceutics, UIC University School of Pharmacy The UIC research team. Rong is an expert in identifying antiviral drugs, Soejarto is a famous botanist, and Fong is a famous pharmacologist.
The extract of cloverleaf was extracted from the leaves, stems and roots of the plant small ribs collected by Soejarto in Cuc Phuong National Park, Hanoi, Vietnam more than 10 years ago. UIC/Hong Kong/Vietnam ICBG analyzed these extracts with thousands of other people as part of their efforts to identify new drugs to identify new anti-AIDS, tuberculosis, malaria and cancer drugs.
Rong and his colleagues focused on the compound patentiflorin A because it inhibits the activity of the enzymes required by the HIV virus. Without this enzyme, the HIV virus will not be able to integrate its genetic code. Go to the DNA of the cell. AZT was the first anti-AIDS drug developed and sold in 1987. It is still the cornerstone of HIV drug cocktails. Its role is to inhibit this enzyme, called reverse transcriptase. Patentiflorin A has a more pronounced inhibitory effect on enzymes in human cells infected with HIV.
“Patentiflorin A is able to inhibit the action of reverse transcriptase more effectively than AZT, and can do this either in the early stages of HIV infection entering the macrophages, or in viral infections. Systematic T cells,” Rong said.
It is also effective against known resistant strains, making it a promising candidate for further development into a new HIV drug.
“Patentiflorin A represents a new type of anti-HIV drug that can be added to current anti-HIV drug cocktails to increase HIV inhibition and prevention.”
Researchers can also synthesize patentiflorin A. “If we can make this medicine in the lab, we don’t need to build a farm to grow and harvest the plants, which requires a lot of financial investment, not to mention its impact on the environment,” Rong said.
Glossary: AZT, an anti-AIDS drug produced by Glaxo Wellcome Pharmaceuticals, which relies on reverse transcription to propagate, while AZT is a reverse transcriptase inhibitor It is also a benchmark drug for the treatment of HIV-infected patients and AIDS patients. Therefore, AZT is listed as the first antiviral drug recommended in the third edition of the National New Drug Development Guide. AZT has a considerable inhibitory effect on HIV.