When someone has severe allergy, the life-threatening effects of exposure are almost instantaneous – skin rash, irritability, breathing, weak pulse, heart heart.
This reaction – anaphylactic shock – has a direct cause and effect. But this process was a psychological puzzler: how is this massive reaction so fast?
Researchers at Herzogas Health were published in the magazine "No 9" magazine Science, Used mouse models to track how immune cells are allocated during anaphylactic shock. They describe a previously unknown mechanism in which newly-discovered immune cells are mainly used for allergens from the vessels of blood vessels, and then use an unusual mechanism for rapid cellular cells. The closure of the potentially exploiting innovative lines of attack is a deadly reaction that bothers about 50 people per year in the United States.
"The central conclusion is that the main players of allergies are denserous cells playing the role of anaphylactic shock," says senior researcher Soros. Abraham, Professor of Doctor of Hospital, Immunology and Molecular Genetics and Microbiology and Humane National University of Singapore, Member of the Developed Infectious Disease Program.
We believe that antihylamic reactions are the main means of antaphylactic reactions, which carry diagnosis – the release of histamine and other inflammatory substances in the blood vessel that flows to systemic shock. But it was previously unknown how cells of cells outside the vascular system were warned to be diagnosed with a circulatory allergen in the blood vessel.
What Abraham and colleagues were observing, the new surface of the dentry cells, which is located on the outer surface of the blood vessels. By using a rash-like dentist who transfers blood vessels, these cells will continually reimburse blood invaders.
When dendrites feel bleeding allergens, dendritic cells will warn the neighboring mass cells in the presence of the conqueror. This communication is unusual, which includes allergenic micro-vectors, with a small allergen-covered ballooning process, which is made from the dandruff cells surface.
"They are well known for their immune function, dandruff cells and active ingredients to reduce the immune cells in the body, organism and body, and actively disseminate antigens that previously could be acquired by immune cells," says first author Hei Wong.
Because these allergenic pains help connect the masses of the cells, the volcanic body, anti-inflammatory mediators are disseminated in the blood vessel, which results in anaphylactic shock.
Further demonstration of the critical role of the dentricular cell In order to facilitate anaphylactic shock, the researchers managed to prevent mice to prevent these allergic reactions to prevent allergic reactions. This new observation may lead to the development of new therapies by calculating dendritic cells.
Additional research is required to know whether the newly described activity of dendrite cells is unknown.
"Although it is a disastrous context of allergens, this function may be needed to fight diseases and actually be useful," Abraham said. "This dendrite cells are designed to detect blood parasites, viruses or bacteria, so we must understand that any other circumstance that they activate until they shut down or interfere with their activities."
In addition to Abraham and Shaw, the authors of the study included: Jutamas souvenirradi, Ilhan Kim, Herman F. Stats, Mozlipa Hanifa and Amanda McLeod.
The works are funded by the National Institutes of Health (U01-AI082107; 620 R01-AI096305; R56-DK095198; R21-AI128727).