Reprogrammed tumor-associated macrophages with photogenesis of reactive oxygen species based on nanopart


ᲐBstract

Abstract imagery

Without termination of the immunosuppressive correctional strategy of tumor microorganisms, cancer immunotherapy generally provides limited clinical benefits to cancer. Tumor-associated macrophages (TMS) is a critical driver of the immune-tumor mucosa microorganisms, which also promotes tumor metastasis. Here we successfully renamed the TAMs antitumor M1 phenotype using precision nanoparticle based reactive oxygen species photogeneration, which showed the highest efficiency and efficiency over lipopolysaccharide stimulation. At the same time, antigen presentations and T-cell drugs are prescribed by tobacco inhibition of lysosomatic proton pump and inhibition of proteolytic activity or promoting the release of cancer associated antigen in cytoplasm. Reproduction of Tumor Lymphocytes (CTL) TAMs and Tumor Lymphocytes (CTL) Recruitment for tumoricidal reactions in tumor and direct memory T-cells. This strategy can effectively eliminate tumors, avoid metastasis and prevent their recurrence, which has a tremendous promise of immunosuppression.

Support information is free at ACS publications website: DOI: 10.1021 / acs.nanolett.8b03568.

  • MAN-PLGA-TAA, MAN-PLGA-N-TAA, MAN-PHP-PLGA, and MAN-PHP-PLGA-N Nanoparticles, Materials for Ceatometric Analysis of Stream, MAN-PLGA, MAN-PLGA-N, MAN-PLGA- TAA, RT-QPCR, Immunohistology, Nanoparticle Biotification, Cytokine Analysis, Western Bloc Analysis, Cataphisin B, Cathepsin L, Cathepsin S, H+Therapy and propaganda, immunization and antigen-specific T-cell detection, tumor growth and survival, TAM destruction (PDF)

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