Australian researchers are taking a closer look at the immunosensitivity of common drugs.
Many drugs have been successfully used to treat diseases, but they also have harmful side effects. Although some drugs are known to have an effect on immune system function, our mechanism for this process is unclear.
The team studied drugs that activate a specific type of immune cell, MAIT cells, and found that some drugs prevent MAIT cells from detecting infection (which plays a major role in our immune system), while others Drugs that activate the immune system are, to some extent, unpopular.
The results of the study were published in the journal Nature Immunology. This study will give people a better understanding of why some people are immune to certain drugs. The results of this study also provide a way to control the effects of MAIT cells to give patients a good prognosis.
Dr. Andrew Keller from the Monash University Institute of Biomedical Research explained that T cells are an integral part of the body’s immune system.
“When T cells find foreign bodies invading, they can detect other cells being infected and activate the immune system to achieve self-protection,” Dr. Andrew Keller said.
“This mechanism depends on T cells knowing what they are looking for, and other cells in the body also provide them with useful information.”
PhD students from the University of Queensland Weijun Xu, using computer models to predict which chemical structures, drugs, or drug-like molecules may have an effect on MAIT cell function. Such compounds include salicylates, non-steroidal anti-inflammatory drugs such as diclofenac and drug metabolites.
Dr. Sidonia Eckle of the University of Melbourne said the results suggest that the hypersensitivity of the drug is inextricably linked to MAIT cells.
“The interaction between MAIT cells and host cells will allow us to better predict and avoid drug abuse, causing physical damage and harm,” she said.
In the future, in terms of treatment, it is possible to control the behavior of MAIT cells, for example, by enhancing or inhibiting the immune response to achieve beneficial clinical effects. “(min1204 204108)