Scientists have discovered decisive biological circuits that regulate lipids and their role in common health


McMaster researchers Bhagwati Gupta and Avijit Mallick. Credit: JD Howell, McMaster University

Little microscopic worms that are naked, scientists understand that complex complex biological paths are well understood, which in general affects the health and aging in humans.


The Macmaster University Biologists team studying these worms C. Elegan, Or nematodes, have discovered that regulation of lipid production and too much or too greasy balance is important for healthy living.

The poll published in the journal PLoS One, Indicate the fundamental process of lipid regulation, which occurs on the path of WNT signaling, with the widely researched genetic distribution, which, while mutating, is directly related to a variety of cancers.

The nummets consider the ideal model of human systems, say scientists, who have been living within 72 hours of duration of maturity, in a total of 3 weeks, which allows researchers to quickly get results of experimental manipulations.

"We will see the history of the whole life in a month and then we can ask questions about how the genes are in this system and what changes are going on as the animals grow and develop," says Baggati Gupta, a biologist at McMaster, whose laboratory has been studying nematode for 15 years.

Gupta and his team co-authors Avigeit Maliski and Ausu Ranavad, both Doctor Candidates – were scattered and intense when they initially discovered that nematodes were transferred to the wrong WNT highway at low lipid levels and died much earlier. Further experiments confirmed that the worms were fed to the lipid level of olive oil, the olexicic acid, and they later lived.

The study found that the genetic control of the lipid storage novel and its potential connection to life. The team is now working to understand how the newly discovered genetic mechanism is associated with the process of lipid aging.

Exceptions may be important, researchers say. For example, the path may be manipulated by drugs to restore the fat levels or are aimed at lipid-related conditions that cause diabetes and diseases such as hypertension, metabolic syndromes and glucose intolerance.

"Elderly is very difficult, everything that we age is wrong," says Gupta. "The sensitivity to the disease increases, the gene will start functioning over time, the muscle degeneration, our physiological changes, fat distribution and accumulation becomes a pathological, metabolic rate, and usually less than eat.

"There are so many ways in the age of the body, and I would say that these researchers are challenging: how should we process critical processes or factors that can be manipulated not just alive but healthy?"


Learn further:
Alpine-related mutation causes sugar-containing cells to lower lipids, study shows

Journal Reference:
PLOS ONE

Provided by:
McMaster University