The team determines how cholesterol moves in cells


Research is the author of Dr. Peter Peterson, professor of pathology and laboratory medicine at David Geffen School of Medicine at UCLA. UCLA Health

Researchers have found that high density lipoproteins, or HDL, are sometimes referred to as "good" cholesterol, moving from the outer wall into the interior of proteins that promotes "bridge" in two parts.


HDL cholesterol is associated with the risk of coronary heart disease over the years. Recent studies have, however, raised questions about the risk of heart disease actually suggests that the HDL cholesterol circulation, rather than its concentration, may be more at risk of risk. In this study, researchers have determined how to define cell cells from the HDL cholesterol cell outer membrane, which were previously secret.

The researchers suspected that the proteins that are called "aster" might be responsible for transferring HDL cholesterol to cells. Asster cells inside the cell into the inside of the endoplasmic reticulum, the network inside the network. The team is the first isolated asteroid region, presumably cholesterol is mandatory and found that the aster is mandatory. The region also effectively transferred cholesterol molecules between two artificial membranes in test tubes.

The team also studied three of the three assistant mice, and confirmed that it is necessary for the cell membrane needed in the endocrine reticulum in the kidneys, which uses cholesterol to create steroid hormones such as cortisol.

Understanding how cholesterol transporting cells can lead to new ways of diagnosis and treatment of high cholesterol and other blood lipid disorders in humans. Changed cholesterol metabolism is related to occasional fatal diseases, including chronic heart disease. This study will facilitate new diagnostic and therapeutic means of new diseases.


Learn further:
In the spring of the sensory cholesterol cells

Მet Information:
Jaspery Saidhu and others Aster proteins promotes the nonveicular plasma membrane that ER cholesterol transported to mammalian cells, Cell (2018). DOI: 10.1016 / j.cell.2018.08.033

Journal Reference:
Cell

Provided by:
University of California, Los Angeles